docosapentaenoate n3 DPA; 22:5n3 to sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Metabolite Accession: GCST90199995
Name: sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.328
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-15.582
Reference Allele:
C
-log10(P):
-124.382
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.186
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.2[1], 4[2]

Denominator Metabolite Explanation:

Sphingolipid synthesis pathway.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the balance between n-3 polyunsaturated fatty acid synthesis, involving FADS1/FADS2, and sphingolipid metabolism, which are distinct but both crucial for membrane composition.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the biosynthesis of DPA (22:5n3) and other polyunsaturated fatty acids.3[1], 8[2], 9[3] This dysregulation impacts inflammatory processes8[4], 10[5] and lipid metabolism11[6], 12[7], 13[8], contributing to the risk of asthma14[9], 15[10], 16[11], 17[12], inflammatory bowel disease18[13], 19[14], 20[15], 21[16], and hypercholesterolemia.12[17], 13[18], 22[19]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data