docosapentaenoate n3 DPA; 22:5n3 to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Metabolite Accession: GCST90200013
Name: sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4246215

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.223
Position:
61564299
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-11.051
Reference Allele:
G
-log10(P):
-63.696
MAF:
0.353
Beta (Num):
-0.143
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.080
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FEN1 FADS1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS desaturase activity, where altered function can impact the balance between omega-3 fatty acid (docosapentaenoate) synthesis and sphingolipid composition.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered FADS activity, influenced by genetic variants, changes the balance of anti-inflammatory docosapentaenoate and pro-inflammatory sphingolipids, potentially contributing to the pathogenesis of dyslipidemia and cholelithiasis which are associated with lipid metabolism disorders and inflammation.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data