docosapentaenoate n3 DPA; 22:5n3 to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.309
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-13.510
Reference Allele:
C
-log10(P):
-94.098
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.167
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

PUFA biosynthesis

Denominator Metabolite Explanation:

Plasmalogen metabolism

Ratio Explanation:

This ratio may reflect the balance between LC-PUFA synthesis and plasmalogen levels, both influenced by FADS enzyme activity on fatty acid precursors.1[1], 2[2], 7[3], 8[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster influence the efficiency of LC-PUFA synthesis, impacting downstream inflammatory and metabolic pathways.9[1], 10[2], 11[3], 12[4], 13[5], 14[6], 15[7], 16[8], 17[9] This altered lipid metabolism is associated with a wide range of inflammation-related and metabolic phenotypes, including cardiovascular diseases, type 2 diabetes, and inflammatory bowel disease.9[10], 10[11], 18[12], 12[13], 15[14], 16[15], 17[16]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data