docosapentaenoate n3 DPA; 22:5n3 to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.273
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-12.264
Reference Allele:
C
-log10(P):
-77.946
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.131
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Glycerophosphoinositol metabolism / Phospholipid metabolism.9[1], 10[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity, where higher activity increases docosapentaenoate (DPA) levels, a polyunsaturated fatty acid, relative to glycerophosphoinositol lipid species.11[1], 12[2], 13[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids.14[1], 15[2], 16[3] This dysregulation of lipid mediators is associated with inflammatory conditions like asthma and IBD, and metabolic disorders including type 2 diabetes and hypercholesterolemia.14[4], 3[5], 17[6], 18[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data