docosapentaenoate n3 DPA; 22:5n3 to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.245
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-11.429
Reference Allele:
A
-log10(P):
-67.984
MAF:
0.344
Beta (Num):
-0.140
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, GPI-anchor biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio may reflect FADS enzyme activity, comparing the synthesis of long-chain omega-3 DPA with the abundance of a specific glycerophospholipid anchor molecule.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS alters desaturase activity, impacting the balance of pro- and anti-inflammatory lipids like DPA.8[1], 9[2], 10[3], 11[4] This dysregulation, reflected in the ratio, likely influences susceptibility to inflammatory conditions (IBD, asthma), lipid disorders (hypercholesterolaemia), and associated cardiometabolic diseases.8[5], 12[6], 11[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data