docosapentaenoate n3 DPA; 22:5n3 to hexadecadienoate (16:2n6)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.092
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
7.643
Reference Allele:
G
-log10(P):
-31.485
MAF:
0.176
Beta (Num):
0.024
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.068
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174546

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.147
Position:
61569830
SE (Ratio):
0.010
Effect Allele:
T
Z-score (Ratio):
-15.238
Reference Allele:
C
-log10(P):
-119.053
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.006
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain PUFA (n-3) biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Long-chain PUFA (n-6) biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects the relative activity of n-3 versus n-6 PUFA biosynthesis pathways, which are both regulated by FADS enzymes.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants influence the balance of n-3 (often anti-inflammatory) and n-6 (often pro-inflammatory) PUFAs.7[1] This balance impacts the risk for inflammatory conditions and cardiovascular diseases like coronary atherosclerosis and myocardial infarction, which are listed as associated phenotypes.9[2], 1[3], 2[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data