docosapentaenoate n3 DPA; 22:5n3 to nisinate (24:6n3)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs9295741

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.175
Position:
10997166
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
9.752
Reference Allele:
C
-log10(P):
-50.069
MAF:
0.420
Beta (Num):
0.056
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.119
SE (Den):
0.021
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 ERVFRD-1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.6[1], 8[2]

Ratio Explanation:

This ratio of docosapentaenoate (22:5n3) to its downstream product nisinate (24:6n3) reflects the efficiency of the omega-3 fatty acid elongation and desaturation pathway influenced by ELOVL2.3[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided; therefore, a causal link between the ELOVL2 gene, the docosapentaenoate (22:5n3) to nisinate (24:6n3) ratio, and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data