docosapentaenoate n3 DPA; 22:5n3 to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.141
Position:
151879761
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
12.420
Reference Allele:
G
-log10(P):
-79.882
MAF:
0.318
Beta (Num):
0.017
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs174549

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.147
Position:
61571382
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-12.933
Reference Allele:
G
-log10(P):
-86.425
MAF:
0.304
Beta (Num):
-0.144
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.003
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs11626972

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.087
Position:
74033594
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
8.054
Reference Allele:
A
-log10(P):
-34.764
MAF:
0.423
Beta (Num):
0.003
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.085
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Long-chain fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

This ratio reflects the efficiency of long-chain polyunsaturated fatty acid synthesis, where FADS1 and FADS2 are key enzymes, relative to the metabolism of other fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity can alter fatty acid profiles, impacting lipid metabolism.9[1] This dysregulation is linked to an increased risk of cholelithiasis and other disorders of lipoprotein metabolism.10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data