docosapentaenoate n3 DPA; 22:5n3 to palmitoleate (16:1n7)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.152
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
13.049
Reference Allele:
G
-log10(P):
-87.940
MAF:
0.176
Beta (Num):
0.024
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174549

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.153
Position:
61571382
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-15.879
Reference Allele:
G
-log10(P):
-129.072
MAF:
0.304
Beta (Num):
-0.144
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Monounsaturated fatty acid biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the balance between polyunsaturated (omega-3) and monounsaturated fatty acid synthesis, which is influenced by FADS1 and SCD enzyme activities.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter desaturase activity, affecting the DPA/palmitoleate ratio. This dysregulation of fatty acid metabolism can influence lipid profiles and inflammation, increasing the risk for cholelithiasis, cardiovascular disease, and other metabolic and inflammatory disorders.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data