docosapentaenoate n3 DPA; 22:5n3 to stearate (18:0)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.129
Position:
61588305
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-12.904
Reference Allele:
A
-log10(P):
-86.045
MAF:
0.344
Beta (Num):
-0.140
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of docosapentaenoate (22:5n3) to stearate (18:0) reflects the enzymatic efficiency of FADS1/FADS2 in converting saturated fatty acids to polyunsaturated fatty acids.1[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the DPA to stearate ratio, impacts the balance of pro- and anti-inflammatory lipids, potentially influencing inflammatory conditions like cholelithiasis, IBD, and disorders of lipoprotein metabolism due to changes in fatty acid pools and signaling.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data