docosapentaenoate n3 DPA; 22:5n3 to palmitate (16:0)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.144
Position:
61581764
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
-15.989
Reference Allele:
T
-log10(P):
-130.821
MAF:
0.308
Beta (Num):
-0.141
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.003
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of docosapentaenoate to palmitate reflects the balance between polyunsaturated and saturated fatty acid synthesis, influenced by FADS1/FADS2 enzyme activity.1[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variations in FADS1/FADS2 alter enzyme activity, impacting the balance of fatty acids.10[1], 11[2] This altered ratio is associated with inflammatory conditions like follicular cysts, potentially due to changes in inflammatory mediator production derived from these fatty acids.12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data