docosapentaenoate n3 DPA; 22:5n3 to myristate (14:0)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.148
Position:
61569830
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
-14.000
Reference Allele:
C
-log10(P):
-100.871
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.006
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

long-chain fatty acid biosynthesis14[1], 15[2], 16[3], 17[4], 18[5], 19[6], 20[7]

Denominator Metabolite Explanation:

Fatty acid biosynthesis21[1], 22[2], 23[3], 24[4], 25[5]

Ratio Explanation:

The ratio reflects the balance between the synthesis of long-chain polyunsaturated fatty acids and saturated fatty acids, influenced by FADS desaturase activity.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS activity, influenced by genetic factors, likely modifies the fatty acid profile, impacting lipid metabolism and inflammatory pathways implicated in cholelithiasis and hypercholesterolemia.26[1], 27[2], 28[3], 29[4], 30[5], 31[6], 32[7], 33[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data