docosapentaenoate n3 DPA; 22:5n3 to margarate (17:0)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.136
Position:
61588305
SE (Ratio):
0.009
Effect Allele:
G
Z-score (Ratio):
-14.380
Reference Allele:
A
-log10(P):
-106.289
MAF:
0.344
Beta (Num):
-0.140
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.003
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid synthesis/metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects the enzymatic activity of FADS1/FADS2 (producing DPA) relative to an odd-chain fatty acid, margarate, often linked to dietary intake.7[1], 5[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter PUFA synthesis, impacting the production of inflammatory mediators.9[1], 10[2] This connects the DPA/margarate ratio to inflammatory conditions like cholelithiasis, IBD, and asthma, and also to lipid metabolism disorders.9[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data