myristoleate (14:1n5) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.150
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-7.675
Reference Allele:
G
-log10(P):
-31.735
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.053
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation6[1], 7[2], 8[3], 9[4]

Ratio Explanation:

An elevated ratio suggests decreased carnitine-dependent fatty acid import and oxidation (denominator) relative to fatty acid synthesis (numerator), potentially due to impaired SLC22A5 function.1[1], 2[2], 5[3], 10[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine uptake, hindering palmitoylcarnitine formation and mitochondrial fatty acid oxidation.1[1], 2[2], 3[3] This can lead to myocardial lipid accumulation and energy deficiency, increasing the risk of myocardial infarction and ischemic heart disease.11[4], 12[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data