myristoleate (14:1n5) to stearidonate (18:4n3)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.119
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.056
Reference Allele:
G
-log10(P):
-34.780
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.022
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.130
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
10.994
Reference Allele:
A
-log10(P):
-63.064
MAF:
0.345
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

De novo lipogenesis

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

The ratio reflects the balance between de novo synthesis of monounsaturated fats and the desaturation of omega-3 polyunsaturated fatty acids, influenced by FADS2 activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS2 activity, influenced by genetic factors, likely impacts the balance of fatty acids, contributing to dyslipidemia and increasing the risk for cholelithiasis and cardiovascular diseases by affecting lipid metabolism and inflammation.2[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data