myristoleate (14:1n5) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Metabolite Accession: GCST90199715

Name: myristoleate (14:1n5)

Hmdb Id: HMDB0002000

Super Pathway: NA

Sub Pathway: NA

Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Metabolite Accession: GCST90199723

Name: 5-dodecenoate (12:1n7)

Hmdb Id: HMDB0000529

Super Pathway: NA

Sub Pathway: NA

Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.059

Position:

151879761

SE (Ratio):

0.007

Effect Allele:

Z-score (Ratio):

8.996

Reference Allele:

-log10(P):

-42.897

MAF:

0.318

Beta (Num):

-0.005

Novel Locus:

Yes ✔️

SE (Num):

0.015

Beta (Den):

-0.064

SE (Den):

0.015

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis; Fatty acid metabolism.3^[1]

Denominator Metabolite Explanation:

Fatty acid metabolism; Fatty acid oxidation.4^[1], 5^[2]

Ratio Explanation:

The ratio may reflect the activity of THEM4, which can hydrolyze both C12 and C14 acyl-CoAs, potentially influencing their relative abundance and downstream metabolism.1^[1], 2^[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data