myristoleate (14:1n5) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.129
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.329
Reference Allele:
G
-log10(P):
-37.043
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio of myristoleate to linolenate reflects the balance between de novo synthesis of monounsaturated fats (via SCD) and the intake/metabolism of polyunsaturated fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SCD gene variation influences the myristoleate to linolenate ratio.1[1], 2[2], 3[3] This altered fatty acid profile is associated with myocardial infarction, hypercholesterolemia, and other cardiometabolic diseases, likely through effects on membrane fluidity, lipid signaling, and inflammation.4[4], 5[5], 6[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data