myristoleate (14:1n5) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174565

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.185
Position:
61591636
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
9.992
Reference Allele:
C
-log10(P):
-52.461
MAF:
0.131
Beta (Num):
0.024
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.161
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of myristoleate to docosapentaenoate (n6) reflects the activity of FADS enzymes, which are involved in the synthesis of long-chain polyunsaturated fatty acids.6[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, influencing the myristoleate to DPA (n6) ratio. This altered lipid profile is associated with an increased risk for cholelithiasis, type 2 diabetes, and hypercholesterolemia.10[1], 1[2], 11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data