myristoleate (14:1n5) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs4149056

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.509
Position:
21331549
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-27.078
Reference Allele:
T
-log10(P):
-370.133
MAF:
0.156
Beta (Num):
0.007
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.516
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

Region: rs62107762

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.128
Position:
15982538
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
8.356
Reference Allele:
C
-log10(P):
-37.277
MAF:
0.296
Beta (Num):
0.031
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and metabolism.11[1], 12[2], 13[3], 14[4], 15[5]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 9[2], 16[3], 17[4], 18[5]

Ratio Explanation:

The ratio of myristoleate to hexadecanedioate may reflect the balance between fatty acid synthesis and omega-oxidation, a pathway in which CYP4F2 is involved.7[1], 8[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity due to the V433M variant can alter fatty acid metabolism, reflected in the myristoleate to hexadecanedioate ratio. This dysregulation of lipid metabolism is a potential contributor to the development of coronary atherosclerosis and cardiac arrhythmias.2[1], 4[2], 5[3], 19[4], 20[5], 21[6], 22[7]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data