myristoleate (14:1n5) to tetradecadienoate (14:2)*

Numerator Metabolite

Metabolite Accession: GCST90199715

Name: myristoleate (14:1n5)

Hmdb Id: HMDB0002000

Super Pathway: NA

Sub Pathway: NA

Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Metabolite Accession: GCST90200187

Name: tetradecadienoate (14:2)*

Hmdb Id: HMDB0000560

Super Pathway: NA

Sub Pathway: NA

Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.118

Position:

151879761

SE (Ratio):

0.011

Effect Allele:

Z-score (Ratio):

11.079

Reference Allele:

-log10(P):

-64.013

MAF:

0.318

Beta (Num):

-0.005

Novel Locus:

SE (Num):

0.015

Beta (Den):

-0.123

SE (Den):

0.016

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4^[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.5^[1], 6^[2]

Ratio Explanation:

This ratio may reflect fatty acid desaturation. A lower ratio suggests increased desaturase activity, converting the monounsaturated myristoleate (14:1n5) to the polyunsaturated tetradecadienoate (14:2).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data