myristoleate (14:1n5) to palmitate (16:0)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.143
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-12.444
Reference Allele:
G
-log10(P):
-80.177
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid desaturation4[1]

Denominator Metabolite Explanation:

De novo fatty acid synthesis5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of myristoleate to palmitate is an index of SCD activity, which converts saturated fatty acids (like myristic acid, a precursor related to palmitate) to monounsaturated fatty acids.1[1], 3[2], 4[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD gene activity influences the myristoleate to palmitate ratio. Altered ratios of saturated to monounsaturated fatty acids are associated with atherosclerosis and myocardial infarction, linking the gene, ratio, and phenotypes.1[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data