myristoleate (14:1n5) to myristate (14:0)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.149
Position:
102075479
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
-16.497
Reference Allele:
G
-log10(P):
-139.114
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.052
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid desaturation3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of Stearoyl-CoA Desaturase (SCD), which converts myristate (14:0) to myristoleate (14:1n5), a key step in lipid metabolism.7[1], 8[2], 9[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in SCD, a key regulator of lipid metabolism, influence the ratio of myristoleate to myristate.1[1], 2[2], 10[3] Altered levels of these fatty acids and changes in SCD activity are associated with an increased risk of coronary atherosclerosis, hypercholesterolemia, and other cardiometabolic diseases.1[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data