myristoleate (14:1n5) to pentadecanoate (15:0)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.139
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-11.637
Reference Allele:
G
-log10(P):
-70.396
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.042
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Diet, endogenous synthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects SCD desaturase activity, converting saturated to monounsaturated fats1[1], 2[2], relative to dietary intake of pentadecanoate, a dairy fat biomarker.5[3], 7[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SCD gene variants influence its enzymatic activity, altering the myristoleate/pentadecanoate ratio.1[1], 2[2] This altered lipid profile is associated with an increased risk for cardiometabolic diseases like myocardial infarction, hypertension, and atherosclerosis, which are listed as associated phenotypes.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data