10-undecenoate (11:1n1) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4149083

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.166
Position:
21380630
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-7.686
Reference Allele:
A
-log10(P):
-31.815
MAF:
0.166
Beta (Num):
-0.064
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.102
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 SLCO1A2 RP11-125O5.2 IAPP SLCO1B7

LLM Analysis

Numerator Metabolite Explanation:

Medium-chain fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Long-chain fatty acid beta-oxidation.6[1]

Ratio Explanation:

The ratio may reflect altered carnitine-dependent fatty acid transport. SLC22A5 deficiency impairs oleoylcarnitine formation, potentially increasing levels of medium-chain fatty acids like 10-undecenoate.1[1], 6[2], 5[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine transport, affecting fatty acid oxidation and increasing uric acid, which is associated with gout.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data