10-undecenoate (11:1n1) to tetradecanedioate (c14-dc)

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs4507958

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.627
Position:
47383041
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
24.411
Reference Allele:
A
-log10(P):
-301.361
MAF:
0.126
Beta (Num):
0.466
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.161
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.9[1], 10[2], 11[3], 12[4]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.13[1], 14[2], 15[3], 16[4]

Ratio Explanation:

The ratio may reflect altered CYP4-mediated omega-oxidation. CYP4A11 metabolizes tetradecanoate's precursor, while CYP4B1 may hydroxylate other fatty acids, influencing substrate availability.17[1], 18[2], 19[3], 4[4], 20[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data