10-undecenoate (11:1n1) to hexadecanedioate (c16-dc)

Numerator Metabolite

Metabolite Accession: GCST90199716

Name: 10-undecenoate (11:1n1)

Hmdb Id: HMDB0033724

Super Pathway: NA

Sub Pathway: NA

Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Metabolite Accession: GCST90199807

Name: hexadecanedioate (c16-dc)

Hmdb Id: HMDB0000672

Super Pathway: NA

Sub Pathway: NA

Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs4507958

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.565

Position:

47383041

SE (Ratio):

0.026

Effect Allele:

Z-score (Ratio):

21.634

Reference Allele:

-log10(P):

-237.325

MAF:

0.126

Beta (Num):

0.466

Novel Locus:

SE (Num):

0.023

Beta (Den):

-0.099

SE (Den):

0.023

No CNV overlap

rQTL cluster:

163

Reaction Distance:

Closest Genes:

CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5^[1], 6^[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.7^[1], 8^[2]

Ratio Explanation:

The ratio may reflect activity of CYP4 family enzymes, where higher values suggest reduced omega-oxidation of fatty acid precursors to dicarboxylic acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data