10-undecenoate (11:1n1) to tridecenedioate (c13:1-dc)*

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Metabolite Accession: GCST90199867
Name: tridecenedioate (c13:1-dc)*
Hmdb Id: HMDB02327
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4507958

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.475
Position:
47383041
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
24.195
Reference Allele:
A
-log10(P):
-296.116
MAF:
0.126
Beta (Num):
0.466
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.009
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs12318075

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.138
Position:
21361587
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-7.858
Reference Allele:
T
-log10(P):
-33.174
MAF:
0.166
Beta (Num):
-0.063
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.075
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Dicarboxylate fatty acid metabolism.9[1], 10[2]

Ratio Explanation:

A reduced SLCO1B1 function may impair hepatic uptake of both the fatty acid 10-undecenoate and dicarboxylic acid tridecenedioate, altering their circulating ratio.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 transporter function is the primary driver for phenotypes like hyperbilirubinemia (Total Bilirubin) and gout.3[1], 4[2] Altered transport of fatty acids like 10-undecenoate and tridecenedioate is likely a secondary effect of this primary genetic dysfunction.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data