10-undecenoate (11:1n1) to n-oleoyltaurine

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs11045883

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.209
Position:
21383516
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-9.097
Reference Allele:
G
-log10(P):
-43.826
MAF:
0.167
Beta (Num):
-0.062
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.147
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 SLCO1A2 RP11-125O5.2 IAPP SLCO1B7

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Fatty acid amide biosynthesis.11[1], 12[2], 13[3]

Ratio Explanation:

Reduced SLCO1B1 function may impair hepatic uptake of both fatty acid derivatives, altering their plasma ratio and reflecting decreased transporter activity.14[1], 15[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function is linked to both gout and elevated bilirubin, a known OATP1B1 substrate.16[1], 17[2], 18[3] The altered fatty acid derivative ratio is likely a biomarker of this impaired transport, which also affects urate and bilirubin homeostasis, connecting the gene to the phenotypes.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data