10-undecenoate (11:1n1) to adipoylcarnitine (c6-dc)

Numerator Metabolite

Metabolite Accession: GCST90199716

Name: 10-undecenoate (11:1n1)

Hmdb Id: HMDB0033724

Super Pathway: NA

Sub Pathway: NA

Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Metabolite Accession: GCST90200018

Name: adipoylcarnitine (c6-dc)

Hmdb Id: HMDB0061677

Super Pathway: NA

Sub Pathway: NA

Inchikey: BSVHAXJKBCWVDA

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.675

Position:

47389613

SE (Ratio):

0.031

Effect Allele:

Z-score (Ratio):

21.960

Reference Allele:

-log10(P):

-244.443

MAF:

0.128

Beta (Num):

0.467

Novel Locus:

SE (Num):

0.023

Beta (Den):

-0.209

SE (Den):

0.022

No CNV overlap

rQTL cluster:

163

Reaction Distance:

Closest Genes:

CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism.6^[1], 7^[2], 8^[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.9^[1], 10^[2]

Ratio Explanation:

Increased 10-undecenoate relative to adipoylcarnitine may suggest altered CYP4-mediated omega-oxidation, where CYP4B1 could hydroxylate the fatty acid precursor to adipoylcarnitine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data