10-undecenoate (11:1n1) to dodecenedioate (c12:1-dc)*

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Structure of dodecenedioate (c12:1-dc)*
Metabolite Accession: GCST90200159
Name: dodecenedioate (c12:1-dc)*
Hmdb Id: HMDB0000933
Super Pathway: NA
Sub Pathway: NA
Inchikey: MAZWDMBCPDUFDJ

Associated Genomic Regions

Region: rs4507958

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.605
Position:
47383041
SE (Ratio):
0.027
Effect Allele:
T
Z-score (Ratio):
22.355
Reference Allele:
A
-log10(P):
-253.218
MAF:
0.126
Beta (Num):
0.466
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.139
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, primarily omega-oxidation.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.9[1], 10[2], 11[3]

Ratio Explanation:

This ratio likely reflects the activity of fatty acid omega-oxidation, where CYP4 enzymes metabolize medium-chain fatty acids like undecenoate and the C12 precursor of dodecenedioate.7[1], 4[2], 1[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided, thus a plausible causal link cannot be established between genetic factors, the metabolite ratio, and a clinical outcome.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data