10-undecenoate (11:1n1) to heptenedioate (c7:1-dc)*

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Metabolite Accession: GCST90200163
Name: heptenedioate (c7:1-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12095130

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.531
Position:
47345926
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
21.859
Reference Allele:
T
-log10(P):
-242.225
MAF:
0.125
Beta (Num):
0.467
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.064
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4B1 CYP4X1 EFCAB14 CYP4Z1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.5[1]

Ratio Explanation:

The ratio may reflect CYP4B1's role in fatty acid metabolism, potentially hydroxylating 10-undecenoate or a precursor, with downstream effects influencing heptenedioate levels.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype link can be established as no associated phenotypes were provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data