sebacate (c10-dc) to tetradecanedioate (c14-dc)

Numerator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs4149026

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.138
Position:
21315415
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
9.643
Reference Allele:
A
-log10(P):
-48.992
MAF:
0.314
Beta (Num):
0.014
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.124
SE (Den):
0.016
No CNV overlap
rQTL cluster:
54
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 LST3 SLCO1B3

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.505
Position:
21331549
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-28.238
Reference Allele:
T
-log10(P):
-402.265
MAF:
0.156
Beta (Num):
0.001
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.506
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation, dicarboxylic acid metabolism.8[1], 9[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, dicarboxylic acid metabolism.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects altered hepatic uptake of medium vs. long-chain dicarboxylic acids, as both are substrates of the OATP1B1 transporter.10[1], 13[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SLCO1B1 variants alter OATP1B1 function, impacting hepatic clearance of substrates.6[1], 2[2] This altered transport can affect plasma levels of various compounds, including dicarboxylic acids and drugs, which is broadly linked to cardiovascular phenotypes and reported drug-induced arrhythmias.14[3], 15[4], 16[5], 17[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data