sebacate (c10-dc) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.515
Position:
21331549
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-27.278
Reference Allele:
T
-log10(P):
-375.585
MAF:
0.156
Beta (Num):
0.001
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.516
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2]

Ratio Explanation:

Reduced SLCO1B1 function likely impairs hepatic uptake of both sebacate and hexadecanedioate, dicarboxylic acids cleared by OATP1B1, altering their circulating ratio.5[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function, indicated by the altered dicarboxylate ratio, impairs hepatic clearance of substances like bilirubin and lipids, contributing to hyperbilirubinemia and potentially coronary atherosclerosis risk.2[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data