sebacate (c10-dc) to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs6587640

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.197
Position:
151955230
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-9.508
Reference Allele:
C
-log10(P):
-47.693
MAF:
0.340
Beta (Num):
-0.100
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 S100A11 THEM4 TCHHL1 TCHH

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1]

Denominator Metabolite Explanation:

Dicarboxylic acid beta-oxidation, Amino acid metabolism.6[1]

Ratio Explanation:

A higher ratio may indicate reduced beta-oxidation of dicarboxylic acids, potentially influenced by THEM4's thioesterase activity on acyl-CoA intermediates of different chain lengths.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A genome-wide association study identified THEM4 as a risk locus for diverticular disease.7[1] Altered fatty acid metabolism, influenced by THEM4, may impact colonic inflammation or cell integrity, contributing to the development of diverticula.8[2], 9[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data