sebacate (c10-dc) to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12132488

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.364
Position:
47389613
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
-11.034
Reference Allele:
C
-log10(P):
-63.505
MAF:
0.126
Beta (Num):
-0.163
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.201
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs2130525

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.208
Position:
151902101
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-9.387
Reference Allele:
C
-log10(P):
-46.538
MAF:
0.392
Beta (Num):
-0.089
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.1[1], 4[2]

Denominator Metabolite Explanation:

Glycine conjugation, xenobiotic metabolism.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects competing metabolic fates for C10 compounds, where altered CYP4B1 activity may shift metabolism towards omega-oxidation (sebacate) over other pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a causal link between the CYP4B1 variant, the metabolic ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data