tauro-beta-muricholate to DHEAS

Numerator Metabolite

Structure of tauro-beta-muricholate
Metabolite Accession: GCST90199719
Name: tauro-beta-muricholate
Hmdb Id: HMDB0000932
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSOLDPYUICCHJX

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.355
Position:
99075038
SE (Ratio):
0.062
Effect Allele:
C
Z-score (Ratio):
21.747
Reference Allele:
T
-log10(P):
-239.771
MAF:
0.050
Beta (Num):
0.932
Novel Locus:
No
SE (Num):
0.046
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Primary bile acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Steroidogenesis; Adrenal androgen biosynthesis6[1], 7[2], 8[3]

Ratio Explanation:

The ratio between tauro-beta-muricholate and DHEAS may reflect a trade-off between bile acid and steroid hormone synthesis, potentially influenced by mitochondrial energy production via ATP5J2.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation near ATP5J2 likely alters mitochondrial ATP production, affecting the balance of energy-intensive bile acid and steroid synthesis pathways. This systemic energy metabolism shift may influence inflammatory and metabolic phenotypes like BMI, C-reactive protein, and white blood cell count.9[1], 3[2], 10[3]

Phenotype Driver:

Gene-centric:ATP5J2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data