tauro-beta-muricholate to 5alpha-androstan-3alpha,17beta-diol monosulfate (1)

Numerator Metabolite

Structure of tauro-beta-muricholate
Metabolite Accession: GCST90199719
Name: tauro-beta-muricholate
Hmdb Id: HMDB0000932
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSOLDPYUICCHJX

Denominator Metabolite

Metabolite Accession: GCST90199858
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
2.272
Position:
99075038
SE (Ratio):
0.073
Effect Allele:
C
Z-score (Ratio):
31.236
Reference Allele:
T
-log10(P):
-491.498
MAF:
0.050
Beta (Num):
0.932
Novel Locus:
No
SE (Num):
0.046
Beta (Den):
-1.340
SE (Den):
0.049
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.5[1], 6[2]

Ratio Explanation:

The ratio may reflect crosstalk between bile acid and androgen metabolism, where increased androgens can influence bile acid synthesis and sulfation.7[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The association of ATP5J2 with this ratio suggests a link between mitochondrial energy production and the balance of bile acid and steroid hormone metabolism. This altered balance may contribute to phenotypes like variations in BMI, C-reactive protein, uric acid, and white blood cell counts.

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data