octanoylcarnitine (c8) to decanoylcarnitine (c10)

Numerator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Denominator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Associated Genomic Regions

Region: rs60782127

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
16
Beta (Ratio):
-0.271
Position:
16142079
SE (Ratio):
0.028
Effect Allele:
T
Z-score (Ratio):
-9.535
Reference Allele:
G
-log10(P):
-47.946
MAF:
0.011
Beta (Num):
-0.397
Novel Locus:
No
SE (Num):
0.072
Beta (Den):
-0.126
SE (Den):
0.072
No CNV overlap
rQTL cluster:
173
Reaction Distance:
NA
Closest Genes:
ABCC1 ABCC6 FOPNL NOMO3 MYH11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects medium-chain fatty acid oxidation efficiency; an altered ratio may suggest disrupted acylcarnitine metabolism or transport, potentially influenced by ABCC1.11[1], 12[2], 13[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A link between the ABCC1 transporter, acylcarnitine levels, and height is suggested by PheWAS, but the biological mechanism is not established; it may involve indirect effects on cellular energy, signaling, or development.14[1]

Phenotype Driver:

Gene-centric:ABCC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data