stearidonate (18:4n3) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs3734398

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.093
Position:
10982973
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
8.428
Reference Allele:
T
-log10(P):
-37.884
MAF:
0.426
Beta (Num):
0.017
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.075
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.1[1], 4[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.1[1], 5[2]

Ratio Explanation:

The ratio of stearidonate to DHA reflects the efficiency of the fatty acid elongation pathway, where lower ELOVL2 activity may lead to higher ratios.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data