stearidonate (18:4n3) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.134
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
8.686
Reference Allele:
G
-log10(P):
-40.121
MAF:
0.176
Beta (Num):
0.022
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174566

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.137
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-11.084
Reference Allele:
A
-log10(P):
-64.063
MAF:
0.345
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.020
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Alpha-linolenic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1]

Ratio Explanation:

This ratio reflects the activity of the FADS2 enzyme, which synthesizes the numerator (stearidonate), an omega-3 fatty acid, while the denominator is unrelated.7[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter fatty acid profiles, impacting lipid metabolism and inflammation.8[1], 9[2], 10[3] This directly links to the associated cardiometabolic phenotypes, including dyslipidemia, cholelithiasis, and ischemic heart disease.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data