stearidonate (18:4n3) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.138
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-11.280
Reference Allele:
A
-log10(P):
-66.279
MAF:
0.345
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.020
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio likely reflects FADS2 activity, which synthesizes the numerator stearidonate, relative to the pool of the denominator 10-nonadecenoate, indicating desaturation efficiency.4[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS alters desaturase activity, changing this ratio and polyunsaturated fatty acid balance.9[1], 10[2] This dysregulates lipid metabolism and inflammation, plausibly contributing to associated phenotypes like cholelithiasis, Type 2 diabetes, and asthma.11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data