stearidonate (18:4n3) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.132
Position:
61592362
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-11.481
Reference Allele:
A
-log10(P):
-68.580
MAF:
0.345
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.014
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1]

Ratio Explanation:

The ratio of stearidonate (18:4n3) to 10-heptadecenoate (17:1n7) reflects the activity of FADS2-mediated omega-3 fatty acid synthesis relative to odd-chain fatty acid levels.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster influence FADS2 activity, altering stearidonate levels.6[1] This dysregulation of polyunsaturated fatty acid metabolism is associated with an increased risk for inflammatory conditions like asthma and metabolic disorders such as Type 2 diabetes and cholelithiasis.7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data