stearidonate (18:4n3) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.250
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-10.909
Reference Allele:
C
-log10(P):
-62.126
MAF:
0.339
Beta (Num):
-0.121
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism5[1]

Ratio Explanation:

The ratio of stearidonate to 1-linoleoyl-GPC (18:2) reflects the activity of FADS2, which synthesizes stearidonate from precursors, against the background of a glycerophospholipid.1[1], 2[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS2 activity, reflected in the stearidonate to 1-linoleoyl-gpc ratio, is associated with changes in lipid profiles, including cholesterol and triglycerides, which are risk factors for cholelithiasis and hypercholesterolemia.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data