stearidonate (18:4n3) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.150
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
10.787
Reference Allele:
G
-log10(P):
-60.788
MAF:
0.176
Beta (Num):
0.022
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174566

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.125
Position:
61592362
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-11.233
Reference Allele:
A
-log10(P):
-65.745
MAF:
0.345
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Monounsaturated fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects the relative activity of FADS2 (producing stearidonate) and SCD (producing palmitoleate), indicating a balance in fatty acid desaturation pathways.7[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster alter desaturase efficiency, affecting the balance between omega-3 (stearidonate) and monounsaturated (palmitoleate) fatty acids.2[1], 9[2], 10[3] This dysregulation of lipid metabolism contributes to the observed risk for cholelithiasis, dyslipidemia, and cardiovascular disease.11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data