stearidonate (18:4n3) to palmitate (16:0)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.119
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-10.165
Reference Allele:
A
-log10(P):
-54.222
MAF:
0.345
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.001
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
10.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Alpha-linolenic acid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.5[1]

Ratio Explanation:

The ratio of stearidonate (18:4n3) to palmitate (16:0) reflects the initial steps of fatty acid desaturation, influenced by FADS2, a key enzyme in this process.3[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster influence the efficiency of polyunsaturated fatty acid synthesis.7[1], 8[2] This altered metabolism is associated with changes in lipid profiles, including cholesterol and triglycerides, and has been linked to an increased risk of disorders of lipoprotein metabolism, cholelithiasis, and asthma.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data