stearidonate (18:4n3) to myristate (14:0)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.128
Position:
61588305
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-10.478
Reference Allele:
A
-log10(P):
-57.480
MAF:
0.343
Beta (Num):
-0.120
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
11.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio of stearidonate (18:4n3) to myristate (14:0) reflects the FADS2-mediated synthesis of omega-3 fatty acids relative to the saturated fatty acid pool.6[1], 7[2], 12[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene activity influences the balance of polyunsaturated fatty acids, which is critical for regulating inflammation and lipid levels.1[1], 13[2], 3[3] This impacts the risk for associated inflammatory and cardiometabolic phenotypes like cholelithiasis, type 2 diabetes, and hypercholesterolemia.14[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data