stearidonate (18:4n3) to pentadecanoate (15:0)

Numerator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.137
Position:
61592362
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-9.933
Reference Allele:
A
-log10(P):
-51.866
MAF:
0.345
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.019
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis3[1]

Denominator Metabolite Explanation:

Odd-chain fatty acid metabolism4[1], 5[2]

Ratio Explanation:

This ratio may reflect the activity of FADS2, which synthesizes stearidonate from its precursor, relative to pentadecanoate, an unrelated dietary odd-chain fatty acid.6[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster alters the activity of FADS enzymes, impacting polyunsaturated fatty acid levels.7[1], 8[2] This dysregulation of lipid metabolism and inflammation is linked to phenotypes like cholelithiasis and hypercholesterolemia.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data