decanoylcarnitine (c10) to 3-hydroxydecanoate

Numerator Metabolite

Structure of decanoylcarnitine (c10)
Metabolite Accession: GCST90199722
Name: decanoylcarnitine (c10)
Hmdb Id: HMDB0000651
Super Pathway: NA
Sub Pathway: NA
Inchikey: LZOSYCMHQXPBFU

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs6684114

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.225
Position:
151928715
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
14.392
Reference Allele:
A
-log10(P):
-106.469
MAF:
0.316
Beta (Num):
0.020
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.205
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.5[1], 6[2]

Ratio Explanation:

An elevated ratio of decanoylcarnitine to 3-hydroxydecanoate can indicate a dysfunction in the ACADM enzyme, leading to impaired beta-oxidation of medium-chain fatty acids.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

With ACADM dysfunction, the breakdown of medium-chain fatty acids is impaired, causing a buildup of upstream metabolites like decanoylcarnitine and intermediates like 3-hydroxydecanoate. No specific phenotype data was provided.1[1], 6[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data