5-dodecenoate (12:1n7) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Metabolite Accession: GCST90199723

Name: 5-dodecenoate (12:1n7)

Hmdb Id: HMDB0000529

Super Pathway: NA

Sub Pathway: NA

Inchikey: IJBFSOLHRKELLR

Denominator Metabolite

Metabolite Accession: GCST90199728

Name: 10-nonadecenoate (19:1n9)

Hmdb Id: HMDB0013622

Super Pathway: NA

Sub Pathway: NA

Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs2130525

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

-0.086

Position:

151902101

SE (Ratio):

0.010

Effect Allele:

Z-score (Ratio):

-8.852

Reference Allele:

-log10(P):

-41.602

MAF:

0.392

Beta (Num):

-0.069

Novel Locus:

Yes ✔️

SE (Num):

0.015

Beta (Den):

0.017

SE (Den):

0.015

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, reduction pathway.4^[1], 5^[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.6^[1]

Ratio Explanation:

The ratio of a medium-chain to a long-chain fatty acid may reflect altered mitochondrial fatty acid beta-oxidation, potentially influenced by THEM4 thioesterase activity.1^[1], 3^[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data