5-dodecenoate (12:1n7) to myristate (14:0)

Numerator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.074
Position:
151879761
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
-7.984
Reference Allele:
G
-log10(P):
-34.187
MAF:
0.318
Beta (Num):
-0.064
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.164
Position:
102075479
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-14.548
Reference Allele:
G
-log10(P):
-108.736
MAF:
0.176
Beta (Num):
-0.112
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.052
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis8[1], 9[2]

Ratio Explanation:

The ratio reflects the balance between fatty acid beta-oxidation and biosynthesis. A lower ratio may indicate increased SCD activity, which is associated with obesity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD gene expression influences the ratio of saturated to monounsaturated fatty acids, impacting triglyceride and cholesterol metabolism.1[1] This alteration is associated with an increased risk of coronary atherosclerosis, hypercholesterolemia, and cholelithiasis, which can be linked to changes in lipid metabolism.1[2], 2[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data